Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 10/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | BMX | P51813 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625602 | 0.91 | FGFR4 (0.40) | FGFR4FGFR1TNK2MAP4K2FGFR3 | |
| SCHEMBL3580197 | 0.88 | FGFR4 (0.40) | FGFR4FGFR1TNK2MAP4K2FGFR3 | |
| SCHEMBL4472920 | 0.87 | FGFR1 (0.46) | FGFR4FGFR1TNK2MAP4K2FGFR3 | |
| SCHEMBL6623008 | 0.86 | FGFR4 (0.43) | FGFR4LCKMAPK14EGFRCSF1R | |
| SCHEMBL3572656 | 0.85 | HTT (0.37) | FGFR4FGFR1TNK2MAP4K2FGFR3 | |
| SCHEMBL6620671 | 0.84 | FGFR4 (0.40) | FGFR4FGFR1TNK2MAP4K2FGFR3 | |
| SCHEMBL6622657 | 0.81 | FGFR4 (0.42) | FGFR4FGFR1FGFR3LCKKDR | |
| SCHEMBL5231241 | 0.81 | FGFR4 (0.52) | FGFR4FGFR1FGFR3LCKKDR | |
| SCHEMBL6622724 | 0.78 | TNK2 (0.43) | FGFR4FGFR1TNK2MAP4K2FGFR3 | |
| SCHEMBL4479243 | 0.78 | TNK2 (0.54) | FGFR4FGFR1TNK2MAP4K2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655651-B2 | Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2010-02-02 | — | — | US | disclosed |
| EP-1789416-B1 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | disclosed |
| US-7494993-B2 | Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20080032970-A1 | Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | HOFFMANN-LA ROCHE INC. | 2008-02-07 | — | — | US | disclosed |
| US-20070232611-A1 | Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCNE AG (CH) | 2007-10-04 | — | — | US | disclosed |
| EP-1789417-A1 | AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| EP-1789416-A2 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-la Roche AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006024486-A2 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-09 | — | — | WO | disclosed |
| WO-2006024487-A1 | AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232611-A1 | Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | DPYD, THPO, DHPS | FGFR4 1075/4885FGFR1 1730/4885TNK2 1671/4885 |
| US-20080032970-A1 | Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | DPYD, GART, DDC | FGFR4 1538/4885FGFR1 2579/4885TNK2 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.