Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 6/20 | 0.57 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.57 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634480 | 0.92 | GNAI3 (0.57) | GNAI3GNAO1GNAI1HTR1AKDM4E | |
| SCHEMBL21303867 | 0.92 | GNAI3 (0.52) | GNAI3GNAO1GNAI1HTR1AKDM4E | |
| SCHEMBL21477161 | 0.92 | GNAI3 (0.52) | GNAI3GNAO1GNAI1HTR1AKDM4E | |
| SCHEMBL23471206 | 0.92 | GNAI3 (0.57) | GNAI3GNAO1GNAI1HTR1AKDM4E | |
| SCHEMBL21367100 | 0.91 | GNAI3 (0.45) | GNAI3GNAO1GNAI1HTR1AS1PR1 | |
| SCHEMBL793522 | 0.89 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HTR1AKDM4E | |
| SCHEMBL21303856 | 0.88 | GNAI3 (0.47) | GNAI3GNAO1GNAI1KDM4EGAA | |
| SCHEMBL11570576 | 0.87 | HRH3 (0.46) | GNAI3GNAO1GNAI1ALDH1A1HRH3 | |
| SCHEMBL10927336 | 0.87 | HRH3 (0.46) | GNAI3GNAO1GNAI1ALDH1A1HRH3 | |
| SCHEMBL11569007 | 0.87 | HRH3 (0.46) | GNAI3GNAO1GNAI1ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | GNAI3 158/4885GNAO1 91/4885GNAI1 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.