Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16827166 | 0.84 | KDM4E (0.56) | KDM4EPKM | |
| SCHEMBL19867111 | 0.81 | HTR4 (0.38) | — | |
| SCHEMBL16827187 | 0.71 | HTR4 (0.43) | KDM4EPKM | |
| SCHEMBL13059914 | 0.71 | KDM4E (0.56) | KDM4EPKMTGFBR1MAPTGPR119 | |
| SCHEMBL16827070 | 0.71 | IL1B (0.45) | HTT | |
| SCHEMBL16827093 | 0.70 | HDAC8 (0.46) | GPR119 | |
| SCHEMBL24201559 | 0.69 | KDM4E (0.42) | KDM4EPKMMAPTGPR119NPC1 | |
| SCHEMBL8206262 | 0.69 | KDM4E (0.64) | KDM4EPKMTGFBR1GPR119KDM1A | |
| SCHEMBL18171071 | 0.68 | HTR4 (0.58) | — | |
| SCHEMBL6980865 | 0.67 | KDM4E (0.61) | KDM4EPKMGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099675-B1 | INDAZOLE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | SUVEN LIFE SCIENCES LTD (IN) | 2018-02-14 | — | — | EP | disclosed |