Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19867223 | 0.80 | KDM4E (0.35) | KDM4E | |
| SCHEMBL22170251 | 0.80 | KDM4E (0.35) | KDM4E | |
| SCHEMBL21100188 | 0.76 | KDM4E (0.33) | KDM4EPOLB | |
| SCHEMBL22170281 | 0.76 | KDM4E (0.33) | KDM4E | |
| SCHEMBL22170262 | 0.75 | KDM4E (0.32) | KDM4E | |
| SCHEMBL19867166 | 0.73 | GAA (0.46) | KDM4EPOLBALDH1A1GAALMNA | |
| SCHEMBL15233624 | 0.71 | NOTUM (0.43) | KDM4EALDH1A1 | |
| SCHEMBL278644 | 0.70 | LMNA (0.40) | KDM4EALDH1A1LMNA | |
| SCHEMBL26954100 | 0.70 | KDM4E (0.43) | KDM4ETSHRPOLBALDH1A1NPC1 | |
| SCHEMBL21150919 | 0.70 | NAAA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |
| WO-2018028721-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | 厦门大学 | 2018-02-15 | — | — | WO | disclosed |