Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 10/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17211718 | 0.80 | CNKSR1 (0.64) | CNKSR1AKT1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL17211657 | 0.77 | CNKSR1 (0.60) | CNKSR1AKT1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL19867362 | 0.76 | CNKSR1 (0.47) | CNKSR1AKT1ALDH1A1MEN1KMT2A | |
| SCHEMBL18160902 | 0.71 | CNKSR1 (0.57) | CNKSR1AKT1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL15811504 | 0.69 | CNKSR1 (0.81) | CNKSR1AKT1ALDH1A1MAPTMEN1 | |
| SCHEMBL18160904 | 0.69 | CNKSR1 (0.50) | CNKSR1AKT1ALDH1A1MEN1KMT2A | |
| SCHEMBL17211661 | 0.67 | CNKSR1 (0.63) | CNKSR1AKT1ALDH1A1MAPTMEN1 | |
| SCHEMBL15811477 | 0.67 | CNKSR1 (0.76) | CNKSR1AKT1ALDH1A1MAPTMEN1 | |
| SCHEMBL17200780 | 0.67 | CNKSR1 (0.76) | CNKSR1AKT1ALDH1A1MAPTMEN1 | |
| SCHEMBL19867339 | 0.66 | CNKSR1 (0.60) | CNKSR1AKT1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |