Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 11/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19867362 | 0.76 | CNKSR1 (0.47) | CNKSR1AKT1MEN1KMT2AL3MBTL1 | |
| SCHEMBL15811504 | 0.71 | CNKSR1 (0.81) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL18160902 | 0.70 | CNKSR1 (0.57) | CNKSR1AKT1L3MBTL1ALDH1A1POLB | |
| SCHEMBL19867333 | 0.69 | CNKSR1 (0.58) | CNKSR1AKT1ALDH1A1 | |
| SCHEMBL18160904 | 0.68 | CNKSR1 (0.50) | CNKSR1AKT1MEN1KMT2AL3MBTL1 | |
| SCHEMBL15811477 | 0.67 | CNKSR1 (0.76) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL20798600 | 0.67 | CNKSR1 (0.76) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL17200780 | 0.67 | CNKSR1 (0.76) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL18160885 | 0.66 | CNKSR1 (0.75) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL17211718 | 0.66 | CNKSR1 (0.64) | CNKSR1AKT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |