Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 1.00 |
| ▸ | PRKACA | P17612 | 6/20 | 1.00 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 1.00 |
| ▸ | AKT2 | P31751 | 3/20 | 1.00 |
| ▸ | DAPK3 | O43293 | 3/20 | 1.00 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 3/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 3/20 | 1.00 |
| ▸ | PAK4 | O96013 | 3/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 3/20 | 1.00 |
| ▸ | PRKCG | P05129 | 3/20 | 1.00 |
| ▸ | PIM1 | P11309 | 3/20 | 1.00 |
| ▸ | PHKG2 | P15735 | 3/20 | 1.00 |
| ▸ | CDK2 | P24941 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | FLT3 | P36888 | 3/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 1.00 |
| ▸ | CSNK1D | P48730 | 3/20 | 1.00 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 1.00 |
| ▸ | GSK3A | P49840 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| A-443654 SCHEMBL29380923 | 1.00 | AKT1 (1.00) | AKT1PRKACAAKT3AKT2DAPK3 | |
| A-443654 SCHEMBL570604 | 1.00 | AKT1 (1.00) | AKT1PRKACAAKT3AKT2DAPK3 | |
| A-443654 SCHEMBL29644958 | 0.89 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2DAPK3 | |
| A-443654 SCHEMBL2738467 | 0.89 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2DAPK3 | |
| A-443654 SCHEMBL6855479 | 0.89 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2DAPK3 | |
| A-443654 SCHEMBL19859268 | 0.89 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2DAPK3 | |
| A-443654 SCHEMBL29374078 | 0.89 | AKT1 (0.85) | AKT1PRKACAAKT3AKT2DAPK3 | |
| SCHEMBL2738468 | 0.87 | AKT1 (0.78) | AKT1PRKACAAKT3AKT2DAPK3 | |
| SCHEMBL6855274 | 0.86 | AKT1 (1.00) | AKT1PRKACAAKT3AKT2DAPK3 | |
| SCHEMBL6854290 | 0.84 | AKT1 (0.81) | AKT1PRKACAAKT3AKT2DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841075-B1 | AGENTS AND METHODS FOR TREATING AND PREVENTING SEBORRHEIC KERATOSIS | MASSACHUSETTS GEN HOSPITAL (US) | 2020-03-18 | — | — | EP | claimed |
| US-20220113311-A1 | Methods of Detecting and Treating a Tumor Expressing PT346 PDK1 | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2022-04-14 | — | — | US | disclosed |
| US-11208478-B2 | Methods of detecting and treating a tumor expressing pT346 PDK1 | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2021-12-28 | — | — | US | disclosed |
| WO-2020132459-A1 | QUINOLINYL-PYRAZINE-CARBOXAMIDE COMPOUNDS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-06-25 | — | — | WO | disclosed |
| US-20190177411-A1 | Methods of Detecting and Treating a Tumor Expressing PT346 PDK1 | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2019-06-13 | — | — | US | disclosed |
| WO-2018031407-A1 | METHODS OF DETECTING AND TREATING A TUMOR EXPRESSING PT346 PDK1 | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2018-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220113311-A1 | Methods of Detecting and Treating a Tumor Expressing PT346 PDK1 | PDK1, PDK2, PCK2 | AKT1 439/4885PRKACA 270/4885AKT3 257/4885 |
| US-11208478-B2 | Methods of detecting and treating a tumor expressing pT346 PDK1 | PDK1, PDK2, PCK2 | AKT1 439/4885PRKACA 270/4885AKT3 257/4885 |
| US-20190177411-A1 | Methods of Detecting and Treating a Tumor Expressing PT346 PDK1 | PDK1, PDK2, PCK2 | AKT1 439/4885PRKACA 270/4885AKT3 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.