Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 13/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413709 | 0.79 | KDR (0.54) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL27889595 | 0.78 | ALDH1A1 (0.52) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL24775576 | 0.77 | KDR (0.46) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL14856741 | 0.76 | CDK8 (0.49) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL296198 | 0.75 | KDR (0.65) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL29325780 | 0.72 | FGFR1 (0.48) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL25469573 | 0.72 | KDR (0.48) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL415173 | 0.72 | KDR (0.54) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL24758368 | 0.72 | FGFR1 (0.47) | KDRFGFR1RIPK1CDK8AXL | |
| SCHEMBL30845320 | 0.72 | FGFR1 (0.47) | KDRFGFR1RIPK1CDK8AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021078301-A1 | PROTEIN DEGRADING AGENT AND USE THEREOF IN TREATMENT OF DISEASES | 上海科技大学 | 2021-04-29 | — | — | WO | disclosed |
| WO-2019185025-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | 正大天晴药业集团股份有限公司 | 2019-10-03 | — | — | WO | disclosed |
| WO-2018029711-A2 | PROCESS FOR THE PREPARATION OF VENETOCLAX | MYLAN LABORATORIES LIMITED (IN) | 2018-02-15 | — | — | WO | disclosed |