Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 11/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856741 | 0.89 | CDK8 (0.49) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL24775576 | 0.83 | KDR (0.46) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL296198 | 0.78 | KDR (0.65) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL19867723 | 0.78 | KDR (0.47) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL27223191 | 0.77 | RIPK1 (0.47) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL413709 | 0.76 | KDR (0.54) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL12410716 | 0.76 | CDK8 (0.67) | CDK8KDRCDK7PLK4DCLK1 | |
| SCHEMBL15416483 | 0.75 | GLA (0.49) | ALDH1A1F2GLAHPGDKDR | |
| SCHEMBL27927096 | 0.75 | ALDH1A1 (0.52) | ALDH1A1F2GLAHPGDPIK3C3 | |
| SCHEMBL24896303 | 0.75 | CDK8 (0.50) | CDK8KDRCDK7PLK4DCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102686587-B | Azaindole glucokinase activators | HOFFMANN LA ROCHE | 2015-05-27 | — | — | CN | disclosed |
| CN-102686587-A | Azaindole glucokinase activators | HOFFMANN LA ROCHE | 2012-09-19 | — | — | CN | disclosed |