Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.37 |
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 3/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443649 | 0.78 | HDAC1 (0.40) | ALDH1A1 | |
| SCHEMBL443817 | 0.78 | MEN1 (0.43) | MMEAGTR1 | |
| SCHEMBL8472410 | 0.78 | MME (0.36) | MMP9MMP2MMEAGTR1 | |
| SCHEMBL8474808 | 0.77 | MME (0.42) | MMEAGTR1 | |
| SCHEMBL443941 | 0.76 | ALDH1A1 (0.42) | ALDH1A1 | |
| SCHEMBL8472130 | 0.73 | EPHX2 (0.37) | MMEAGTR1 | |
| SCHEMBL8472795 | 0.73 | MME (0.38) | MMEAGTR1 | |
| SCHEMBL1989 | 0.72 | AGTR1 (0.40) | AGTR1 | |
| SCHEMBL1990 | 0.72 | LTB4R2 (0.56) | AGTR1 | |
| SCHEMBL1988 | 0.72 | LTB4R2 (0.56) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |