Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 8/20 | 0.48 |
| ▸ | HRH1 | P35367 | 6/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12425273 | 0.87 | HTR6 (0.55) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL1989342 | 0.81 | TAAR1 (0.47) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL12561247 | 0.80 | CHRNA7 (0.55) | ALDH1A1KDM4EHTR6DRD3DRD2 | |
| SCHEMBL12425198 | 0.79 | HRH1 (0.48) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL1991912 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL1992066 | 0.77 | CHRNA7 (0.44) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL1992069 | 0.77 | CHRNA7 (0.44) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL1991064 | 0.77 | KDM4E (0.39) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL1986973 | 0.76 | CHRNA7 (0.45) | ALDH1A1KDM4EHTR6HRH1ADRA2A | |
| SCHEMBL2190070 | 0.73 | CHRNA7 (0.61) | ALDH1A1KDM4EHTR6DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152308-A1 | AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | claimed |
| US-8809532-B2 | Aza-ring fused indole and indoline derivatives | ABBVIE INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20110152308-A1 | AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152308-A1 | AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES | INMT, IDO1, IDO2 | ALDH1A1 231/4885KDM4E 326/4885HTR6 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.