Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 2/20 | 0.47 |
| ▸ | ACP1 | P24666 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16928548 | 0.84 | NMT1 (0.48) | NMT1ACP1CHRNB4CHRNA3MEN1 | |
| SCHEMBL19873488 | 0.84 | GBA1 (0.50) | NMT1ACP1CHRNB4CHRNA3MEN1 | |
| SCHEMBL19873468 | 0.83 | NMT1 (0.48) | NMT1ACP1CHRNB4CHRNA3MEN1 | |
| SCHEMBL16927978 | 0.83 | HRH3 (0.46) | MEN1KMT2AHRH3HTR6KDM4E | |
| SCHEMBL16928055 | 0.81 | HTR6 (0.45) | ACP1MEN1KMT2AHRH3HRH1 | |
| SCHEMBL17721582 | 0.81 | ACP1 (0.45) | NMT1ACP1CHRNB4CHRNA3MEN1 | |
| SCHEMBL17721487 | 0.78 | TLR9 (0.47) | NMT1ACP1CHRNB4CHRNA3MEN1 | |
| SCHEMBL16928411 | 0.78 | HTR6 (0.46) | MEN1KMT2AHTR6POLB | |
| SCHEMBL16928011 | 0.77 | ACP1 (0.48) | NMT1ACP1HRH3HRH2HRH1 | |
| SCHEMBL19873509 | 0.76 | ACHE (0.43) | MEN1KMT2AHTR6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351538-A1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | The United States of America, as represented by The Secretary of The Army, on behalf of Walter Reed Army Institute of Research (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-2970153-B1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | THE US SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INSTITUTE OF RESEARCH (US) | 2018-02-21 | — | — | EP | disclosed |