Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.45 |
| ▸ | ACP1 | P24666 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | KMT5A | Q9NQR1 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | PGK1 | P00558 | 2/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16927922 | 0.94 | CYP1A2 (0.43) | KDM1AEHMT2RCOR1ACP1HTR1A | |
| SCHEMBL16928246 | 0.89 | ACP1 (0.47) | KDM1AEHMT2RCOR1ACP1HTR1A | |
| SCHEMBL16928020 | 0.83 | PGK1 (0.47) | KDM1AEHMT2RCOR1ACP1KMT5A | |
| SCHEMBL16928250 | 0.83 | CYP1A2 (0.49) | ACP1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL19873534 | 0.82 | KDM1A (0.45) | KDM1AEHMT2RCOR1SLC2A1 | |
| SCHEMBL16928556 | 0.82 | SMYD2 (0.45) | ACP1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL17721582 | 0.82 | ACP1 (0.45) | ACP1HRH3TLR9TLR7SLC2A1 | |
| SCHEMBL16928055 | 0.80 | HTR6 (0.45) | KDM1AEHMT2RCOR1ACP1HTR1A | |
| SCHEMBL19873469 | 0.80 | GBA1 (0.56) | KDM1AEHMT2RCOR1HTR1ADRD2 | |
| SCHEMBL16928434 | 0.80 | ACP1 (0.56) | ACP1HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351538-A1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | The United States of America, as represented by The Secretary of The Army, on behalf of Walter Reed Army Institute of Research (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-2970153-B1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | THE US SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INSTITUTE OF RESEARCH (US) | 2018-02-21 | — | — | EP | disclosed |