Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 17/20 | 0.70 |
| ▸ | PKLR | P30613 | 10/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710921 | 0.85 | PKM (0.73) | PKMPKLRNPC1RAB9AL3MBTL1 | |
| SCHEMBL1722758 | 0.83 | PKM (1.00) | PKMPKLRNPC1RAB9AHTT | |
| SCHEMBL1722816 | 0.82 | PKM (1.00) | PKMPKLRNPC1RAB9AL3MBTL1 | |
| SCHEMBL1725568 | 0.82 | PKM (1.00) | PKMPKLRNPC1RAB9AHTT | |
| SCHEMBL1722730 | 0.80 | L3MBTL1 (1.00) | PKMPKLRNPC1RAB9AL3MBTL1 | |
| SCHEMBL1711139 | 0.79 | PKM (0.72) | PKMPKLRNPC1RAB9AL3MBTL1 | |
| SCHEMBL1722929 | 0.77 | PKM (0.72) | PKMPKLRNPC1RAB9AL3MBTL1 | |
| SCHEMBL1722951 | 0.77 | PKM (1.00) | PKMPKLRNPC1RAB9AHTT | |
| SCHEMBL2950538 | 0.77 | PKM (1.00) | PKMPKLRNPC1RAB9AL3MBTL1 | |
| SCHEMBL1722916 | 0.76 | PKM (1.00) | PKMPKLRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3372230-B1 | PYRUVATE KINASE ACTIVATORS FOR USE FOR INCREASING LIFETIME OF THE RED BLOOD CELLS AND TREATING ANEMIA | AGIOS PHARMACEUTICALS INC (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3372230-A1 | PYRUVATE KINASE ACTIVATORS FOR USE FOR INCREASING LIFETIME OF THE RED BLOOD CELLS AND TREATING ANEMIA | Agios Pharmaceuticals, Inc. (US) | 2018-09-12 | — | — | EP | disclosed |
| EP-2704719-B1 | PYRUVATE KINASE ACTIVATORS FOR USE FOR INCREASING LIFETIME OF THE RED BLOOD CELLS AND TREATING ANEMIA | AGIOS PHARMACEUTICALS INC (US) | 2018-02-21 | — | — | EP | disclosed |