Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 14/20 | 0.48 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.48 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.37 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873617 | 1.00 | LPAR1 (0.48) | LPAR1LPAR3NAAAABCC3ABCC4 | |
| SCHEMBL22260988 | 0.92 | LPAR1 (0.40) | LPAR1LPAR3NAAAAPP | |
| SCHEMBL22260989 | 0.92 | LPAR1 (0.40) | LPAR1LPAR3NAAAAPP | |
| SCHEMBL19873660 | 0.90 | LPAR1 (0.39) | LPAR1LPAR3NAAAAPP | |
| SCHEMBL19873662 | 0.90 | LPAR1 (0.39) | LPAR1LPAR3NAAAAPP | |
| SCHEMBL19873569 | 0.89 | LPAR1 (0.43) | LPAR1LPAR3NAAACYP2C9APP | |
| SCHEMBL19873568 | 0.89 | LPAR1 (0.43) | LPAR1LPAR3NAAACYP2C9APP | |
| SCHEMBL19873602 | 0.89 | LPAR1 (0.49) | LPAR1LPAR3NAAAABCC3ABCC4 | |
| SCHEMBL19873603 | 0.89 | LPAR1 (0.49) | LPAR1LPAR3NAAAABCC3ABCC4 | |
| SCHEMBL19873551 | 0.89 | CHRNB2 (0.43) | LPAR1LPAR3NAAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |