Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873659 | 0.93 | AKR1C3 (0.32) | LPAR1AKR1C3AKR1C2ENPP2TACR2 | |
| SCHEMBL19873609 | 0.92 | APP (0.32) | LPAR1CHRM3APPLPAR3 | |
| SCHEMBL19873580 | 0.90 | ENPP2 (0.33) | LPAR1CHRM3ENPP2LPAR3JAK2 | |
| SCHEMBL19873624 | 0.90 | JAK2 (0.40) | LPAR1CHRM3AKR1C3AKR1C2JAK2 | |
| SCHEMBL19873578 | 0.90 | LPAR1 (0.43) | LPAR1CHRM3ENPP2LPAR3 | |
| SCHEMBL19873575 | 0.90 | LPAR1 (0.43) | LPAR1CHRM3ENPP2LPAR3 | |
| SCHEMBL19873661 | 0.89 | LPAR1 (0.39) | LPAR1CHRM3JAK2 | |
| SCHEMBL19873664 | 0.89 | LPAR1 (0.39) | LPAR1CHRM3JAK2 | |
| SCHEMBL19873607 | 0.86 | LPAR1 (0.38) | LPAR1CHRM3APPLPAR3 | |
| SCHEMBL19873572 | 0.86 | CHRM3 (0.37) | LPAR1CHRM3APPAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |