Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19886997 | 0.87 | CYP4A11 (0.53) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL12176925 | 0.81 | LOXL2 (0.65) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL70185 | 0.79 | CYP4A11 (0.75) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL15437144 | 0.78 | MEN1 (0.65) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL12294453 | 0.78 | MEN1 (0.65) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL16420936 | 0.78 | CCR6 (0.52) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL5733406 | 0.77 | CYP4A11 (0.72) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL3566972 | 0.77 | LOXL2 (0.58) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL230590 | 0.76 | LOXL2 (0.72) | LOXL2CYP4A11CCR6HKDC1TP53 | |
| SCHEMBL17429664 | 0.75 | CYP4A11 (0.60) | LOXL2CYP4A11CCR6HKDC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | ELI LILLY AND COMPANY (US) | 2021-03-02 | — | — | US | disclosed |
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | ELI LILLY AND COMPANY (US) | 2021-03-02 | — | — | US | disclosed |
| CN-109563070-B | Fused thiophene derivatives as NAPI-IIB inhibitors | 伊莱利利公司 | 2021-02-26 | — | — | CN | disclosed |
| EP-3497091-B1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | LILLY CO ELI (US) | 2020-10-07 | — | — | EP | disclosed |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | ELI LILLY AND COMPANY | 2020-01-30 | — | — | US | disclosed |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | ELI LILLY AND COMPANY | 2020-01-30 | — | — | US | disclosed |
| EP-3497091-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | Eli Lilly and Company (US) | 2019-06-19 | — | — | EP | disclosed |
| CN-109563070-A | Fused thiophene derivative as NAPI-IIB inhibitor | 伊莱利利公司 | 2019-04-02 | — | — | CN | disclosed |
| WO-2018034883-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | ELI LILLY AND COMPANY (US) | 2018-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | SLC34A2, ALPI, SLC34A1 | LOXL2 2552/4885CYP4A11 846/4885CCR6 4293/4885 |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | SLC34A2, ALPI, SLC34A1 | LOXL2 2552/4885CYP4A11 846/4885CCR6 4293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.