Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987486 | 0.95 | CNR1 (0.49) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1986508 | 0.95 | CNR1 (0.45) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1985005 | 0.94 | CNR1 (0.49) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1986178 | 0.92 | CNR1 (0.42) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1988289 | 0.92 | ALDH1A1 (0.44) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1985064 | 0.90 | CNR1 (0.45) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1985957 | 0.88 | CNR1 (0.44) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1992594 | 0.87 | CNR1 (0.43) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL12563350 | 0.87 | CYP2C19 (0.43) | CNR1CYP2C19USP2ALDH1A1KDM4E | |
| SCHEMBL1985657 | 0.87 | CNR1 (0.45) | CNR1CYP2C19USP2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680102-B2 | Pyrrole derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2014-03-25 | — | — | US | disclosed |
| US-8680102-B2 | Pyrrole derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2014-03-25 | — | — | US | disclosed |
| US-20110152320-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2011-06-23 | — | — | US | disclosed |
| US-20110152320-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2011-06-23 | — | — | US | disclosed |
| US-20110152320-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2011-06-23 | — | — | US | disclosed |
| WO-2009141532-A2 | PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152320-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | CNR1, CNR2, GPR18 | CNR1 1/4885CYP2C19 678/4885USP2 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.