Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 20/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 16/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20212706 | 0.91 | HCRTR2 (0.51) | HCRTR2HCRTR1NR1I2ADRA2BKCNH2 | |
| SCHEMBL19893893 | 0.90 | HCRTR2 (0.59) | HCRTR2HCRTR1 | |
| SCHEMBL19893987 | 0.88 | HCRTR2 (0.57) | HCRTR2HCRTR1 | |
| SCHEMBL19894084 | 0.88 | HCRTR2 (0.57) | HCRTR2HCRTR1 | |
| SCHEMBL19894028 | 0.85 | HCRTR1 (0.34) | HCRTR2HCRTR1NR1I2ADRA2BKCNH2 | |
| SCHEMBL19893971 | 0.84 | HCRTR1 (0.44) | HCRTR2HCRTR1 | |
| SCHEMBL20223598 | 0.83 | HCRTR2 (0.52) | HCRTR2HCRTR1NR1I2ADRA2BKCNH2 | |
| SCHEMBL19893874 | 0.83 | HCRTR2 (0.53) | HCRTR2HCRTR1 | |
| SCHEMBL19893911 | 0.83 | HCRTR2 (0.58) | HCRTR2HCRTR1NR1I2ADRA2BKCNH2 | |
| SCHEMBL19893868 | 0.81 | HCRTR2 (0.55) | HCRTR2HCRTR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287454-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |
| US-10131653-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-11-20 | — | — | US | disclosed |
| US-20180155333-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | US | disclosed |
| US-20180155333-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | US | disclosed |
| US-20180155333-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | US | disclosed |
| EP-3287454-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155333-A1 | Heterocyclic Compound | HCRTR1, HCRTR2, OXTR | HCRTR2 2/4885HCRTR1 1/4885NR1I2 199/4885 |
| US-10131653-B2 | Heterocyclic compound | HCRTR1, HCRTR2, OXTR | HCRTR2 2/4885HCRTR1 1/4885NR1I2 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.