Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 9/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19893971 | 0.85 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL19894085 | 0.85 | HCRTR2 (0.50) | HCRTR1HCRTR2NR1I2ADRA2BKCNH2 | |
| SCHEMBL19894072 | 0.83 | HCRTR1 (0.37) | HCRTR1HCRTR2P2RX7 | |
| SCHEMBL22383467 | 0.81 | CCKBR (0.32) | HCRTR1HCRTR2NR1I2ADRA2BKCNH2 | |
| SCHEMBL19893927 | 0.79 | HCRTR1 (0.40) | HCRTR1HCRTR2MGLL | |
| SCHEMBL19894143 | 0.79 | HCRTR2 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL19893988 | 0.78 | SORD (0.33) | HCRTR1HCRTR2KMT2A | |
| SCHEMBL19894084 | 0.77 | HCRTR2 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL19893987 | 0.77 | HCRTR2 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL20212706 | 0.76 | HCRTR2 (0.51) | HCRTR1HCRTR2NR1I2ADRA2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287454-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |
| US-10131653-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-11-20 | — | — | US | disclosed |
| US-20180155333-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | US | disclosed |
| EP-3287454-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155333-A1 | Heterocyclic Compound | HCRTR1, HCRTR2, OXTR | HCRTR1 1/4885HCRTR2 2/4885NR1I2 199/4885 |
| US-10131653-B2 | Heterocyclic compound | HCRTR1, HCRTR2, OXTR | HCRTR1 1/4885HCRTR2 2/4885NR1I2 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.