Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19901007 | 0.86 | NPC1 (0.60) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL19900857 | 0.81 | NPC1 (0.62) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL28327199 | 0.81 | NPC1 (0.66) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL507242 | 0.78 | RAB9A (0.66) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL18062419 | 0.78 | NPC1 (0.66) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| Trifluoroacetic Acid SCHEMBL5025946 | 0.75 | NPC1 (0.82) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL11988932 | 0.75 | NPC1 (0.66) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL2665689 | 0.74 | TDP1 (0.63) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| SCHEMBL192332 | 0.74 | NPC1 (1.00) | NPC1RAB9ATDP1KDM4EHKDC1 | |
| Hydrochloric Acid SCHEMBL4255724 | 0.72 | NPC1 (0.96) | NPC1RAB9ATDP1KDM4EHKDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504205-A1 | HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS | Ardelyx, Inc. (US) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018039386-A1 | HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS | ARDELYX, INC. (US) | 2018-03-01 | — | — | WO | disclosed |