Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.82 |
| ▸ | RAB9A | P51151 | 12/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192332 | 0.91 | NPC1 (1.00) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL10347638 | 0.89 | NPC1 (0.96) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| Hydrochloric Acid SCHEMBL4255724 | 0.89 | NPC1 (0.96) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| Trifluoroacetic Acid SCHEMBL3492401 | 0.85 | NPC1 (0.59) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| Trifluoroacetic Acid SCHEMBL5028767 | 0.82 | NPC1 (0.54) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL19901007 | 0.78 | NPC1 (0.60) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| Benzo[D]Thiazole SCHEMBL27637923 | 0.78 | ALDH1A1 (0.66) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL261022 | 0.77 | NPC1 (0.74) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL30917341 | 0.77 | NPC1 (0.74) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL1819290 | 0.76 | NPC1 (0.72) | NPC1RAB9AKDM4EHKDC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981883-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007086800-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |