Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | GAK | O14976 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.63 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.63 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.63 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.58 |
| ▸ | DMPK | Q09013 | 1/20 | 0.58 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30578944 | 1.00 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL17155448 | 1.00 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL30059558 | 1.00 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL29400172 | 1.00 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL17155656 | 1.00 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL30059525 | 1.00 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL17143249 | 0.92 | AAK1 (0.85) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL30578941 | 0.90 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL30059554 | 0.90 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT | |
| SCHEMBL20154451 | 0.90 | AAK1 (1.00) | AAK1CYP3A4GAKROCK2CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115484951-A | AAK1 inhibitors for the treatment of viral infections | 莱西肯医药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| US-20210277001-A1 | BIARYL KINASE INHIBITORS | Cosmic Pet LLC | 2021-09-09 | — | — | US | disclosed |
| US-10981910-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-20 | — | — | US | disclosed |
| CN-112142655-A | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-108368084-B | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-10-16 | — | — | CN | disclosed |
| US-20200317671-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-10723734-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-07-28 | — | — | US | disclosed |
| US-10544120-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-01-28 | — | — | US | disclosed |
| US-10351563-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-07-16 | — | — | US | disclosed |
| US-20190048006-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-14 | — | — | US | disclosed |
| US-20180134704-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-17 | — | — | US | disclosed |
| US-9902722-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134704-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
| US-10981910-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
| US-20210277001-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
| US-20200317671-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
| US-10544120-B2 | Biaryl kinase inhibitors | AAK1, CAMKK1, CAMKK2 | AAK1 1/4885CYP3A4 4285/4885GAK 73/4885 |
| US-20190048006-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
| US-10351563-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
| US-10723734-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885GAK 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.