Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2737299 | 0.83 | CYP2D6 (0.47) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL16955343 | 0.80 | CYP2D6 (0.44) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL18793687 | 0.80 | CYP2D6 (0.54) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL13778067 | 0.77 | CRHR1 (0.45) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL19217960 | 0.76 | CA12 (0.54) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL22260376 | 0.76 | CA12 (0.54) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL14488865 | 0.76 | TAAR1 (0.43) | KMT2A | |
| SCHEMBL18713924 | 0.74 | CRHR1 (0.47) | CYP2D6ADRA2AADRA1AHTR2AACHE | |
| SCHEMBL27461377 | 0.74 | CYP1A2 (0.41) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL6372641 | 0.74 | PTGS2 (0.57) | AKR1C3AKR1C2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902703-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2018-02-27 | — | — | US | disclosed |