Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25769638 | 0.84 | CYP2D6 (0.39) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL17826032 | 0.83 | MAPT (0.44) | CYP2D6CYP2C19MMP8CA1MAPT | |
| SCHEMBL7359306 | 0.81 | ECE1 (0.44) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL7359311 | 0.81 | ECE1 (0.44) | CYP2D6CYP2C19MMP1MMP8EPHX1 | |
| SCHEMBL6010230 | 0.80 | CA1 (0.46) | CA1CA2EPHX1 | |
| SCHEMBL21322181 | 0.80 | MAPT (0.46) | CYP2D6CYP2C19MAPT | |
| SCHEMBL564048 | 0.80 | MAPT (0.46) | CYP2D6CYP2C19MAPT | |
| SCHEMBL13741705 | 0.79 | — | — | |
| SCHEMBL3854088 | 0.79 | — | — | |
| SCHEMBL23760621 | 0.79 | ENPEP (0.33) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902688-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2018-02-27 | — | — | US | disclosed |