Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 5/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4824672 | 0.98 | CA1 (0.44) | CA1CA2EPHX1SLC15A1SLC1A3 | |
| SCHEMBL19475787 | 0.82 | CA2 (0.50) | CA1CA2EPHX1SLC15A1SLC1A3 | |
| SCHEMBL19901822 | 0.80 | CYP2D6 (0.38) | CA1CA2EPHX1 | |
| SCHEMBL12743627 | 0.79 | CA2 (0.47) | CA1CA2EPHX1SLC15A1SLC1A3 | |
| SCHEMBL13707903 | 0.77 | CA2 (0.48) | CA1CA2EPHX1SLC15A1SLC1A3 | |
| SCHEMBL3248461 | 0.76 | CA2 (0.52) | CA1CA2EPHX1SLC15A1SLC1A3 | |
| SCHEMBL17826032 | 0.76 | MAPT (0.44) | CA1 | |
| SCHEMBL14687523 | 0.76 | CA2 (0.52) | CA1CA2EPHX1SLC15A1SLC1A3 | |
| SCHEMBL15381234 | 0.76 | CA1 (0.38) | CA1CA2SLC15A1DPP7DPP8 | |
| SCHEMBL15381235 | 0.76 | CA1 (0.38) | CA1CA2SLC15A1DPP7DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656359-A2 | MACROCYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005018545-A2 | MACROCYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2005-03-03 | — | — | WO | disclosed |