Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427907 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM4EALDH1A1ALOX15POLB | |
| SCHEMBL7305308 | 0.83 | POLB (0.48) | KDM4EALDH1A1ALOX15POLBMMP8 | |
| SCHEMBL2146033 | 0.81 | PLAU (0.36) | KDM4EALDH1A1POLBTSHRPLAU | |
| SCHEMBL16886888 | 0.81 | PLAU (0.36) | KDM4EALDH1A1POLBTSHRPLAU | |
| SCHEMBL16886885 | 0.81 | PLAU (0.36) | KDM4EALDH1A1POLBTSHRPLAU | |
| SCHEMBL11102646 | 0.80 | MMP8 (0.35) | POLBFKBP1AMMP8MMP12MMP13 | |
| SCHEMBL27873435 | 0.79 | PLAU (0.40) | ALDH1A1POLBMMP8MMP12MMP13 | |
| Hydrochloric Acid SCHEMBL18173830 | 0.77 | PLAU (0.36) | POLBMMP8MMP12MMP13PLAU | |
| SCHEMBL18198031 | 0.76 | EPHX2 (0.38) | KDM4EALOX15POLBTSHRF2 | |
| SCHEMBL18198027 | 0.76 | EPHX2 (0.38) | KDM4EALOX15POLBTSHRF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902726-B2 | Pyridone-sulfone morphinan analogs as opioid receptor ligands | PURDUE PHARMA L.P. (US) | 2018-02-27 | — | — | US | disclosed |