Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902741 | 0.84 | KDM4E (0.52) | TRPV1GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL19902747 | 0.80 | ATM (0.46) | EGLN1ATMTRPV1GAAKMT2A | |
| SCHEMBL16491925 | 0.80 | ATM (0.41) | EGLN1ATMTRPV1GAAKMT2A | |
| SCHEMBL19902740 | 0.75 | GRM4 (0.46) | KMT2AKDM4EMAPT | |
| SCHEMBL16489218 | 0.72 | ATM (0.46) | EGLN1ATMGAAKMT2A | |
| SCHEMBL18132543 | 0.68 | KDM4E (0.57) | EGLN1ATMTRPV1GAAKMT2A | |
| SCHEMBL18132536 | 0.68 | KDM4E (0.65) | EGLN1ATMTRPV1GAAKMT2A | |
| SCHEMBL25656256 | 0.68 | KDM4E (0.43) | GAAALDH1A1KDM4EALOX15LMNA | |
| Hydrochloric Acid SCHEMBL29177044 | 0.67 | KDM4E (0.42) | ALDH1A1KDM4EALOX15LMNASMN1; SMN2 | |
| SCHEMBL28143802 | 0.67 | F2 (0.48) | KMT2ASAE1UBA2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |