Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902741 | 0.82 | KDM4E (0.52) | MAPTRAB9ANPC1NPSR1KMT2A | |
| SCHEMBL19902756 | 0.76 | BLM (0.42) | GRM4MAPTBLMRAB9ANPC1 | |
| SCHEMBL19902735 | 0.75 | EGLN1 (0.46) | MAPTKMT2AKDM4E | |
| SCHEMBL15886259 | 0.71 | GRM4 (0.56) | GRM4BACE1KDM4E | |
| SCHEMBL19902738 | 0.68 | RAB9A (0.46) | GRM4MAPTRAB9ANPC1NPSR1 | |
| SCHEMBL12054147 | 0.68 | ALDH1A1 (0.44) | KDRLCKFYNCSF1RLYN | |
| SCHEMBL16489227 | 0.68 | GRM4 (0.48) | GRM4MAPTRAB9ANPC1NPSR1 | |
| SCHEMBL15886346 | 0.67 | TSHR (0.69) | MAPTRAB9ANPC1KMT2AKDM4E | |
| SCHEMBL25656256 | 0.66 | KDM4E (0.43) | MAPTBLMNPSR1KDM4E | |
| SCHEMBL16489209 | 0.66 | NPC1 (0.52) | RAB9ANPC1NPSR1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |