Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902734 | 0.84 | KDM4E (0.49) | ALDH1A1SMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL16489218 | 0.80 | ATM (0.46) | ATMEGLN1KMT2AGAA | |
| SCHEMBL19902735 | 0.80 | EGLN1 (0.46) | ATMEGLN1DHODHALDH1A1LMNA | |
| SCHEMBL19902738 | 0.78 | RAB9A (0.46) | ALDH1A1LMNASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL17064036 | 0.76 | P2RX7 (0.38) | ALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL19902802 | 0.74 | KDM4E (0.47) | ALDH1A1SMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL1460028 | 0.73 | P2RX7 (0.46) | ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL16491925 | 0.72 | ATM (0.41) | ATMEGLN1ALDH1A1LMNAKMT2A | |
| SCHEMBL16469273 | 0.70 | L3MBTL1 (0.46) | ALDH1A1LMNASMN1; SMN2KMT2AGAA | |
| SCHEMBL5056591 | 0.69 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |