Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902937 | 0.87 | KDM4E (0.58) | KDM4EHCRTR1HCRTR2ALOX15TSHR | |
| SCHEMBL19894159 | 0.86 | HCRTR1 (0.59) | KDM4EALDH1A1CYP2C9CYP2C19HCRTR1 | |
| SCHEMBL20223578 | 0.85 | L3MBTL1 (0.51) | KDM4EHCRTR1HCRTR2ALOX15TSHR | |
| SCHEMBL19894157 | 0.85 | HCRTR1 (0.48) | ALDH1A1HCRTR1HCRTR2ALOX15TSHR | |
| SCHEMBL19894052 | 0.82 | HCRTR1 (0.45) | KDM4EALDH1A1HCRTR1HCRTR2ALOX15 | |
| SCHEMBL20223582 | 0.82 | MEN1 (0.43) | KDM4EALDH1A1HCRTR1HCRTR2TSHR | |
| SCHEMBL19893994 | 0.82 | GBA1 (0.57) | KDM4EALDH1A1KMT2APDE2AMAPT | |
| SCHEMBL19894126 | 0.81 | HCRTR1 (0.58) | KDM4EALDH1A1HCRTR1HCRTR2TSHR | |
| SCHEMBL19894151 | 0.80 | GBA1 (0.59) | KDM4EALDH1A1KMT2AHPGD | |
| SCHEMBL20223579 | 0.78 | PDE2A (0.45) | KDM4EALDH1A1KMT2APDE2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287454-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |
| US-20180155333-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | US | disclosed |
| US-20180155333-A1 | Heterocyclic Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-07 | — | — | US | disclosed |
| EP-3287454-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155333-A1 | Heterocyclic Compound | HCRTR1, HCRTR2, OXTR | KDM4E 2226/4885ALDH1A1 500/4885CYP1A2 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.