Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 3/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.41 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.41 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1990402 | 1.00 | KMT2A (0.47) | KMT2ASMN1; SMN2FFAR1FFAR4FOLH1 | |
| SCHEMBL1989783 | 0.91 | KMT2A (0.44) | KMT2ASMN1; SMN2FFAR1FFAR4FOLH1 | |
| SCHEMBL1992690 | 0.90 | FOLH1 (0.42) | KMT2ASMN1; SMN2FFAR1FFAR4FOLH1 | |
| SCHEMBL1992692 | 0.90 | FOLH1 (0.42) | KMT2ASMN1; SMN2FFAR1FFAR4FOLH1 | |
| SCHEMBL27809704 | 0.89 | KMT2A (0.49) | KMT2ASMN1; SMN2FFAR1FFAR4FOLH1 | |
| SCHEMBL27809705 | 0.89 | KMT2A (0.49) | KMT2ASMN1; SMN2FFAR1FFAR4FOLH1 | |
| SCHEMBL1783943 | 0.85 | KMT2A (0.47) | KMT2ASMN1; SMN2FOLH1PTGER1 | |
| SCHEMBL2166135 | 0.85 | KMT2A (0.47) | KMT2ASMN1; SMN2FOLH1PTGER1 | |
| SCHEMBL2167632 | 0.85 | KMT2A (0.47) | KMT2ASMN1; SMN2FOLH1PTGER1 | |
| SCHEMBL1990350 | 0.85 | PTGER1 (0.51) | KMT2ASMN1; SMN2FFAR1FFAR4CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152227-A1 | DEUTERIUM LABELLED DERIVATIVES OF 3-(2-HYDROXY-5-METHYPHENYL)-N,N-DIISOPROPYL-3-PHENYLPROPYLAMINE AND METHODS OF USE THEREOF | CONCERT PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | US | disclosed |
| CN-102089262-A | Derivatives of 3- (2-hydroxy-5-methylphenyl) -N, N-diisopropyl-3-amphetamine and methods of use thereof | CONCERT PHARMACEUTICALS INC | 2011-06-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152227-A1 | DEUTERIUM LABELLED DERIVATIVES OF 3-(2-HYDROXY-5-METHYPHENYL)-N,N-DIISOPROPYL-3-PHENYLPROPYLAMINE AND METHODS OF USE THEREOF | ADRB3, CHRM3, QDPR | KMT2A 2758/4885SMN1; SMN2 2545/4885FFAR1 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.