Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991408 | 0.87 | TRPV4 (0.34) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL1989787 | 0.83 | KCNH2 (0.38) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL1992226 | 0.83 | ALDH1A1 (0.40) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL1993836 | 0.81 | TRPV4 (0.38) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL2000181 | 0.80 | ALDH1A1 (0.38) | TRPV4ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5442053 | 0.78 | TRPV4 (0.46) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL1996822 | 0.77 | ALDH1A1 (0.54) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL10179967 | 0.76 | TRPV4 (0.34) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL1991165 | 0.76 | KDM4E (0.40) | TRPV4ALDH1A1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL1990180 | 0.76 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2C9MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866310-B1 | 2,3-SUBSTITUTED FUSED PYRIMIDIN-4(3H)-ONES AS VR1 ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2012-07-11 | — | — | EP | disclosed |
| US-20110152242-A1 | 2,3-Substituted Fused Pyrimidin -4 (3H)-Ones as VR1 Antagonists | MERCK SHARP & DOHME LTD. (GB) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152242-A1 | 2,3-Substituted Fused Pyrimidin -4 (3H)-Ones as VR1 Antagonists | NR2C2, NR3C2, NR2E3 | PDE10A 4237/4885TRPV4 1580/4885ALDH1A1 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.