Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319886 | 0.79 | POLB (0.54) | ABL1POLBPIK3CA | |
| SCHEMBL15391188 | 0.78 | ABL1 (0.63) | ABL1KCNH2 | |
| SCHEMBL16860273 | 0.78 | ABL1 (0.63) | ABL1KCNH2 | |
| SCHEMBL19904273 | 0.77 | ABL1 (0.73) | ABL1KCNH2 | |
| SCHEMBL19904280 | 0.75 | ABL1 (0.73) | ABL1KCNH2 | |
| SCHEMBL20319862 | 0.73 | STK4 (0.53) | ABL1POLBPIK3CA | |
| SCHEMBL20319865 | 0.73 | STK4 (0.53) | POLBPIK3CA | |
| SCHEMBL25705102 | 0.71 | ABL1 (0.65) | ABL1KCNH2 | |
| SCHEMBL3957333 | 0.70 | POLB (0.59) | POLBPIK3CA | |
| SCHEMBL3947541 | 0.67 | POLB (0.55) | POLBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858988-B1 | BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |