Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 4/20 | 0.53 |
| ▸ | STK3 | Q13188 | 4/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2703788 | 0.88 | CNR2 (0.52) | STK4STK3LRRK2CNR2NPC1 | |
| SCHEMBL20319886 | 0.88 | POLB (0.54) | STK4STK3LRRK2POLBKMO | |
| SCHEMBL20319862 | 0.86 | STK4 (0.53) | STK4STK3LRRK2CNR2POLB | |
| SCHEMBL3957333 | 0.78 | POLB (0.59) | POLBKMOPIK3CAEGLN1MAPT | |
| SCHEMBL2704464 | 0.75 | CNR1 (0.54) | CNR2MAP4K4NPSR1EGLN1CNR1 | |
| SCHEMBL19904255 | 0.73 | ABL1 (0.48) | POLBPIK3CA | |
| SCHEMBL17478716 | 0.72 | PRKAB2 (0.50) | LRRK2CNR2POLBKMOPIK3CA | |
| SCHEMBL31301757 | 0.71 | LRRK2 (0.58) | STK4STK3LRRK2 | |
| SCHEMBL4252921 | 0.71 | SLC2A1 (0.67) | NPC1RAB9AMAPK1MEN1KMT2A | |
| SCHEMBL16919646 | 0.70 | PIK3CA (0.60) | PIK3CAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018116285-A1 | SUBSTITUTED MORPHOLINE DERIVATIVES AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-06-28 | — | — | WO | disclosed |