Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 2/20 | 0.53 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319886 | 0.88 | POLB (0.54) | STK4STK3LRRK2POLBABL1 | |
| SCHEMBL20319865 | 0.86 | STK4 (0.53) | STK4STK3LRRK2POLBKMO | |
| SCHEMBL2703788 | 0.74 | CNR2 (0.52) | STK4STK3LRRK2EGLN1CNR2 | |
| SCHEMBL27335823 | 0.74 | HPGDS (0.51) | ABL1KMOEGLN1KDM5AKDM4C | |
| SCHEMBL19904255 | 0.73 | ABL1 (0.48) | POLBABL1PIK3CA | |
| SCHEMBL3957333 | 0.72 | POLB (0.59) | POLBKMOPIK3CAEGLN1TP53 | |
| SCHEMBL3947541 | 0.72 | POLB (0.55) | POLBKMOPRKDCPIK3CA | |
| SCHEMBL16919646 | 0.70 | PIK3CA (0.60) | PIK3CAEGLN1TP53 | |
| SCHEMBL1366015 | 0.70 | HPGDS (0.55) | KMOKDM5AKDM4CKDM5B | |
| SCHEMBL18395133 | 0.70 | POLB (0.48) | POLBKMOPIK3CACNR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018116285-A1 | SUBSTITUTED MORPHOLINE DERIVATIVES AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-06-28 | — | — | WO | disclosed |