⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193239 | 0.78 | CA1 (0.30) | — | |
| SCHEMBL8873944 | 0.76 | ALOX15 (0.35) | — | |
| SCHEMBL17865057 | 0.72 | — | — | |
| SCHEMBL28696338 | 0.72 | MMP3 (0.30) | — | |
| SCHEMBL10434475 | 0.71 | CYP19A1 (0.34) | — | |
| SCHEMBL9874197 | 0.71 | PTPN1 (0.32) | — | |
| SCHEMBL9874195 | 0.71 | PTPN1 (0.32) | — | |
| SCHEMBL918423 | 0.70 | — | — | |
| SCHEMBL20885382 | 0.70 | — | — | |
| SCHEMBL12693922 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907394-B1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-29 | — | — | EP | disclosed |
| US-7759498-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V (BE) | 2010-07-20 | — | — | US | disclosed |
| US-7338973-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-04 | — | — | US | disclosed |
| US-20060116513-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| US-20060116415-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| US-4250336-A | CATALYSTS COMPRISING A MIXTURE OF OXIDES OF GROUP 8 OR 1 METALS AND GROUP 2A, 3B, 4A, OR 4B METALS; VAPOR PHASE | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-10 | — | — | US | disclosed |