Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGCG | Q16739 | 9/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904508 | 0.94 | UGCG (0.42) | UGCGNOTUMACACBHRH1CCR3 | |
| SCHEMBL19904573 | 0.93 | HTR1A (0.40) | UGCGNOTUMACACB | |
| SCHEMBL19904682 | 0.92 | UGCG (0.48) | UGCGNOTUMFFAR4HRH1CCR3 | |
| SCHEMBL19904572 | 0.89 | FFAR4 (0.47) | NOTUMACACBFFAR4HRH1CCR3 | |
| SCHEMBL16695270 | 0.85 | UGCG (0.58) | UGCG | |
| SCHEMBL16695259 | 0.85 | UGCG (0.58) | UGCG | |
| SCHEMBL18094823 | 0.85 | UGCG (0.58) | UGCG | |
| SCHEMBL24503292 | 0.85 | UGCG (0.45) | UGCGHRH1CCR3 | |
| SCHEMBL19904316 | 0.85 | UGCG (0.43) | UGCGNOTUMACACBHRH1CCR3 | |
| SCHEMBL19904428 | 0.85 | UGCG (0.43) | UGCGNOTUMACACBHRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |