Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 11/20 | 0.43 |
| ▸ | ACACA | Q13085 | 2/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904546 | 1.00 | ACACB (0.43) | ACACBACACADEGS1NOTUMSSTR1 | |
| SCHEMBL19904662 | 0.92 | ACACB (0.43) | ACACBACACANOTUMTSHR | |
| SCHEMBL19904433 | 0.88 | GPR119 (0.42) | ACACBDEGS1NOTUMSSTR1SSTR3 | |
| SCHEMBL16695267 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM | |
| SCHEMBL16695165 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM | |
| SCHEMBL19894585 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM | |
| SCHEMBL29604591 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM | |
| SCHEMBL18094916 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM | |
| SCHEMBL16695266 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM | |
| SCHEMBL19894464 | 0.83 | ACACB (0.46) | ACACBACACADEGS1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |