Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904670 | 0.79 | BACE1 (0.42) | CSNK2A1GLASMN1; SMN2TAAR1 | |
| SCHEMBL30780976 | 0.79 | GLA (0.51) | CSNK2A1GLASMN1; SMN2PNMTTAAR1 | |
| SCHEMBL16695091 | 0.79 | CSNK2A1 (0.53) | CSNK2A1SIGMAR1UTS2R | |
| SCHEMBL16595899 | 0.79 | CSNK2A1 (0.53) | CSNK2A1SIGMAR1 | |
| SCHEMBL2369166 | 0.78 | CSNK2A1 (1.00) | CSNK2A1RORCKMO | |
| SCHEMBL16695116 | 0.78 | CSNK2A1 (0.52) | CSNK2A1SIGMAR1 | |
| SCHEMBL6348746 | 0.78 | KDM4E (0.56) | CSNK2A1GLASMN1; SMN2PNMTTAAR1 | |
| SCHEMBL9845094 | 0.76 | KDM4E (0.53) | CSNK2A1GLAPNMTTAAR1 | |
| SCHEMBL7324772 | 0.75 | PDE4B (0.55) | CSNK2A1 | |
| SCHEMBL16695133 | 0.75 | CSNK2A1 (0.56) | CSNK2A1SIGMAR1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |