Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904450 | 0.81 | MEN1 (0.39) | — | |
| SCHEMBL19904416 | 0.80 | ABCB1 (0.44) | — | |
| SCHEMBL19904536 | 0.79 | CSNK2A1 (0.64) | CSNK2A1TAAR1GLASMN1; SMN2 | |
| SCHEMBL19904479 | 0.79 | HRH3 (0.45) | — | |
| SCHEMBL19904510 | 0.77 | ABCB1 (0.43) | PDE4B | |
| SCHEMBL7324772 | 0.76 | PDE4B (0.55) | CSNK2A1KDM4EATMPDE4B | |
| SCHEMBL23469221 | 0.75 | TAAR1 (0.51) | TAAR1KDM4EATM | |
| SCHEMBL5185058 | 0.74 | BACE1 (0.55) | BACE1TAAR1 | |
| SCHEMBL19904400 | 0.74 | PDE4D (0.45) | PDE4B | |
| SCHEMBL9845094 | 0.73 | KDM4E (0.53) | BACE1CSNK2A1TAAR1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |