Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.45 |
| ▸ | PDE4A | P27815 | 8/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904450 | 0.92 | MEN1 (0.39) | MEN1GAAKMT2A | |
| SCHEMBL19904670 | 0.74 | BACE1 (0.42) | PDE4B | |
| SCHEMBL19904683 | 0.73 | SIGMAR1 (0.38) | MEN1GAAKMT2A | |
| SCHEMBL13186813 | 0.73 | SYK (0.63) | PDE4DPDE4APDE4BPDE4CTUBB4A | |
| SCHEMBL19904397 | 0.71 | DDB1 (0.45) | — | |
| SCHEMBL19904416 | 0.69 | ABCB1 (0.44) | — | |
| SCHEMBL5702483 | 0.69 | KAT2B (0.56) | PDE4DPDE4APDE4BPDE4CSYK | |
| SCHEMBL19904479 | 0.68 | HRH3 (0.45) | — | |
| SCHEMBL19904510 | 0.68 | ABCB1 (0.43) | PDE4B | |
| SCHEMBL9845132 | 0.67 | SIGMAR1 (0.49) | PDE4BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |