Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 15/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16664964 | 0.92 | PRKDC (0.41) | FAAHPRKDCMAPK14MAPK13MAPK12 | |
| SCHEMBL17634608 | 0.92 | PRKDC (0.41) | FAAHPRKDCMAPK14MAPK13MAPK12 | |
| SCHEMBL20842620 | 0.91 | FAAH (0.34) | FAAHPRKDCMAPK14MAPK13MAPK12 | |
| SCHEMBL22838685 | 0.86 | PRKDC (0.32) | FAAHPRKDCMAPK1 | |
| SCHEMBL19905243 | 0.84 | TRPV1 (0.39) | FAAHPRKDCMAPK1 | |
| SCHEMBL17634635 | 0.83 | PRKDC (0.40) | FAAHPRKDCMAPK14MAPK1 | |
| SCHEMBL17634609 | 0.83 | PRKDC (0.43) | FAAHPRKDCMAPK1 | |
| SCHEMBL19905345 | 0.83 | FAAH (0.38) | FAAHPRKDC | |
| SCHEMBL18627044 | 0.82 | PRKDC (0.40) | FAAHPRKDCMAPK1 | |
| SCHEMBL17874642 | 0.82 | PRKDC (0.40) | FAAHPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |