Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 13/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17634599 | 0.91 | TRPV1 (0.40) | TRPV1FAAHPRMT5WDR77KDM4E | |
| SCHEMBL22838651 | 0.86 | TRPV1 (0.41) | TRPV1FAAHPRMT5WDR77KDM4E | |
| SCHEMBL15343256 | 0.84 | PRKDC (0.39) | TRPV1FAAHKDM4EALDH1A1TP53 | |
| SCHEMBL19905147 | 0.84 | FAAH (0.35) | FAAHMAPK1PRKDC | |
| SCHEMBL17634610 | 0.81 | PRKDC (0.39) | FAAHKDM4EALDH1A1TP53CYP1A2 | |
| SCHEMBL19355124 | 0.81 | PRKDC (0.39) | FAAHKDM4EALDH1A1TP53CYP1A2 | |
| SCHEMBL19355264 | 0.80 | TRPV1 (0.42) | TRPV1PRMT5WDR77KDM4EALDH1A1 | |
| SCHEMBL22838638 | 0.80 | PRKDC (0.35) | FAAHKDM4EALDH1A1TP53CYP1A2 | |
| SCHEMBL22838448 | 0.79 | TLR9 (0.36) | FAAHKDM4EALDH1A1TP53CYP1A2 | |
| SCHEMBL20373242 | 0.79 | PRKDC (0.37) | TRPV1FAAHKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |