Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2268819 | 1.00 | PKM (0.47) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2266409 | 1.00 | PKM (0.47) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2266416 | 1.00 | PKM (0.47) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2264085 | 0.83 | PKM (0.50) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2272299 | 0.81 | PGR (0.55) | PKMAKR1B1CMA1AHRPDE7A | |
| SCHEMBL25255334 | 0.79 | MEN1 (0.46) | PKMAKR1B1CMA1AHRHTR6 | |
| SCHEMBL13731904 | 0.76 | AKR1B1 (0.44) | PKMAKR1B1CMA1AHRPDE7A | |
| SCHEMBL23836087 | 0.76 | AKR1B1 (0.44) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL23835849 | 0.76 | AKR1B1 (0.44) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL5344885 | 0.74 | AHR (0.46) | PKMAKR1B1KCNQ3KCNQ2KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684880-B1 | DISPIROPYRROLIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2018-02-28 | — | — | EP | disclosed |