Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ICMT | O60725 | 2/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993195 | 0.88 | SERPINE1 (0.55) | SLC22A12ADRA1DTP53MAPTSERPINE1 | |
| SCHEMBL2000207 | 0.87 | MEN1 (0.51) | SLC22A12TP53MAPTSERPINE1ALDH1A1 | |
| SCHEMBL1991908 | 0.86 | ADRA1D (0.55) | SLC22A12ADRA1DMAPTRXFP1SERPINE1 | |
| SCHEMBL1993436 | 0.86 | GAA (0.52) | SLC22A12TP53RXFP1ICMTSERPINE1 | |
| SCHEMBL1994563 | 0.86 | ADRA1D (0.54) | SLC22A12ADRA1DTP53MAPTRXFP1 | |
| SCHEMBL5388266 | 0.84 | NPSR1 (0.57) | ADRA1DTP53MAPTICMTF10 | |
| SCHEMBL5464879 | 0.83 | SLC22A12 (0.45) | SLC22A12ADRA1DSERPINE1F10ALDH1A1 | |
| SCHEMBL1993115 | 0.82 | PDE4A (0.48) | SLC22A12ICMTSERPINE1F10PDE4A | |
| SCHEMBL1995310 | 0.81 | ADRA1D (0.51) | SLC22A12ADRA1DMAPTRXFP1SERPINE1 | |
| SCHEMBL1992798 | 0.81 | SLC22A12 (0.57) | SLC22A12MAPTALDH1A1LMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371281-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS LLC (US) | 2016-06-21 | — | — | US | claimed |
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2015-10-22 | — | — | US | claimed |
| US-20150038542-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 AND TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS LLC | 2015-02-05 | — | — | US | claimed |
| US-20130078215-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2013-03-28 | — | — | US | claimed |
| US-20110150825-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2011-06-23 | — | — | US | claimed |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-12-06 | — | — | US | claimed |
| US-9371281-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2015-10-22 | — | — | US | disclosed |
| US-20150038542-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 AND TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS LLC | 2015-02-05 | — | — | US | disclosed |
| US-8900565-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130156727-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130078215-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
| US-8338416-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYLICS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20110150825-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-7820711-B2 | Uses of selective inhibitors of HDAC8 for treatment of T-cell proliferative disorders | PHARMACYCLICS INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20090203010-A1 | MSMB-gene based diagnosis, staging and prognosis of prostate cancer | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2009-08-13 | — | — | US | disclosed |
| WO-2009089598-A2 | MSMB-GENE METHYLATION BASED DIAGNOSIS, STAGING AND PROGNOSIS OF PROSTATE CANCER | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2009-07-23 | — | — | WO | disclosed |
| US-20080112889-A1 | Uses of Selective Inhibitors of HDAC8 for Treatment of T-Cell Proliferative Disorders | PHARMACYCLICS, INC. (US) | 2008-05-15 | — | — | US | disclosed |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | SLC22A12 3265/4885ADRA1D 3283/4885TP53 2209/4885 |
| US-20080112889-A1 | Uses of Selective Inhibitors of HDAC8 for Treatment of T-Cell Proliferative Disorders | HDAC8, HDAC5, HDAC7 | SLC22A12 2871/4885ADRA1D 4429/4885TP53 483/4885 |
| US-20110150825-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | HDAC8, HDAC2, HDAC7 | SLC22A12 4465/4885ADRA1D 4462/4885TP53 4293/4885 |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | SLC22A12 3265/4885ADRA1D 3283/4885TP53 2209/4885 |
| US-20130078215-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | HDAC8, HDAC2, HDAC7 | SLC22A12 4465/4885ADRA1D 4462/4885TP53 4293/4885 |
| US-20090203010-A1 | MSMB-gene based diagnosis, staging and prognosis of prostate cancer | MAT2B, DNMT3B, SHBG | SLC22A12 2619/4885ADRA1D 3260/4885TP53 483/4885 |
| US-20150038542-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 AND TREATMENT OF INFLAMMATORY CONDITIONS | HDAC8, HDAC2, HDAC7 | SLC22A12 4457/4885ADRA1D 4400/4885TP53 4283/4885 |
| US-20130156727-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | SLC22A12 3265/4885ADRA1D 3283/4885TP53 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.