Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19906069 | 0.90 | EGFR (0.35) | EGFRSHMT1SHMT2IDH1KDM4E | |
| SCHEMBL19906131 | 0.87 | KDM4E (0.35) | EGFRSHMT1SHMT2IDH1KDM4E | |
| SCHEMBL19906087 | 0.86 | KDM4E (0.32) | SHMT1SHMT2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL19906150 | 0.86 | RORC (0.33) | SHMT1SHMT2KDM4EPTGS1CYP2C19 | |
| SCHEMBL19906391 | 0.85 | KDM4E (0.33) | KDM4ESMN1; SMN2LMNAPTGDR2PPARD | |
| SCHEMBL19906374 | 0.83 | POLQ (0.33) | KDM4EPTGS1CYP2C19PTGDR2 | |
| SCHEMBL19906106 | 0.83 | EIF4EBP1 (0.34) | EIF4EBP1KDM2BKDM4CPPARD | |
| SCHEMBL19906032 | 0.83 | HRH4 (0.36) | KDM4ELMNAEIF4EBP1PPARD | |
| SCHEMBL19906017 | 0.82 | KDM4E (0.32) | KDM4ESMN1; SMN2LMNAPTGDR2EIF4EBP1 | |
| SCHEMBL19906161 | 0.82 | KDM4E (0.35) | SHMT1SHMT2KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070081-B1 | BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES INC (US) | 2018-02-28 | — | — | EP | disclosed |