Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602786 | 0.88 | AR (0.37) | ARTAS2R8PLA2G7ROCK2PTGDR2 | |
| SCHEMBL19908474 | 0.78 | ALK (0.54) | ROCK2ALKALDH1A1NTRK1 | |
| SCHEMBL1600425 | 0.77 | NTRK1 (0.49) | ALKKDM4EALDH1A1SMN1; SMN2NTRK1 | |
| SCHEMBL14387471 | 0.74 | ALK (0.59) | ALKNTRK1 | |
| SCHEMBL1601018 | 0.72 | ALK (0.76) | ALK | |
| SCHEMBL1601019 | 0.72 | ALK (0.76) | ALK | |
| SCHEMBL19908477 | 0.70 | ALK (0.64) | ALKKDM4EALDH1A1NTRK1AURKA | |
| SCHEMBL19908479 | 0.67 | ALK (0.43) | ALKEDNRBEDNRANTRK1AURKA | |
| SCHEMBL19908280 | 0.66 | ALK (0.41) | ALKEDNRBEDNRASMN1; SMN2 | |
| SCHEMBL1601778 | 0.66 | ALK (0.53) | ROCK2PTGDR2ALKEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |