Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.39 |
| ▸ | EDNRA | P25101 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601292 | 0.86 | ALK (0.41) | ALKEDNRBEDNRACHRM1 | |
| SCHEMBL14387480 | 0.81 | ALK (0.37) | ALKEDNRBEDNRAGRIN1GRIN2B | |
| SCHEMBL19908479 | 0.79 | ALK (0.43) | ALKEDNRBEDNRACSF1RGRIN1 | |
| SCHEMBL14387485 | 0.78 | KMT2A (0.39) | ALKEDNRBEDNRAGAASMN1; SMN2 | |
| SCHEMBL19908258 | 0.78 | ALK (0.43) | ALKGAASMN1; SMN2 | |
| SCHEMBL19908483 | 0.78 | ALK (0.51) | ALKEDNRBEDNRAGAASMN1; SMN2 | |
| SCHEMBL19908302 | 0.76 | EDNRB (0.47) | ALKEDNRBEDNRA | |
| SCHEMBL19908214 | 0.75 | TRAP1 (0.38) | ALKGAASMN1; SMN2HSP90AA1HSP90B1 | |
| SCHEMBL17813461 | 0.75 | BRPF1 (0.42) | SMN1; SMN2PIK3CAMTORPDE3BPDE3A | |
| SCHEMBL1602412 | 0.74 | ALK (0.57) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |