Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | MERTK | Q12866 | 3/20 | 0.33 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600623 | 0.85 | ALK (0.42) | ALKMERTKKCNH2 | |
| SCHEMBL1600585 | 0.82 | BMPR1B (0.41) | ALKMERTKKCNH2 | |
| SCHEMBL1601658 | 0.68 | NPC1 (0.45) | ALKKCNH2 | |
| SCHEMBL1601867 | 0.66 | KCNH2 (0.44) | ALKKCNH2 | |
| SCHEMBL19908273 | 0.66 | ABL1 (0.47) | KCNH2 | |
| SCHEMBL1600576 | 0.65 | ALK (0.42) | ALKKCNH2 | |
| SCHEMBL14387407 | 0.65 | SLC6A7 (0.44) | ALKKCNH2 | |
| SCHEMBL1600719 | 0.65 | SLC6A7 (0.44) | ALKKCNH2 | |
| SCHEMBL1602674 | 0.64 | BMPR1B (0.41) | ALKKCNH2 | |
| SCHEMBL1602736 | 0.62 | BMPR1B (0.51) | ALKTNIKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |